Authors: Sara Carucci; Alessandro Zuddas; Angelico Lampis; Kenneth K. C. Man; Carla Balia; Jan Buitelaar; Marina Danckaerts; Ralf W. Dittmann; Federica Donno; Bruno Falissard; Antonella Gagliano; Peter Garas; Alexander Häge; Chris Hollis; Sarah K. Inglis; Kerstin Konrad; Hanna Kovshoff; Elizabeth Liddle; Suzanne McCarthy; Antje Neubert; Peter Nagy; Eric Rosenthal; Edmund J. S. Sonuga-Barke; Ian C. K. Wong; Tobias Banaschewski; David Coghill · Research

Can ADHD Medications Like Methylphenidate Affect Growth and Puberty?

A comprehensive look at how ADHD medications impact physical development and maturation in children and adolescents

Source: Carucci, S., Zuddas, A., Lampis, A., Man, K. K. C., Balia, C., Buitelaar, J., ... & Coghill, D. (2024). The Impact of Methylphenidate on Pubertal Maturation and Bone Age in ADHD Children and Adolescents: Results from the ADDUCE Project. Journal of Attention Disorders, 28(5), 722-739. https://doi.org/10.1177/10870547241226726

What you need to know

  • Methylphenidate treatment does not appear to cause significant delays in puberty or sexual development
  • While some minor effects on growth were observed, these were generally small and not clinically concerning
  • Regular monitoring of height, weight, and development is still recommended for children on ADHD medications

Understanding Growth and ADHD Medications

For parents of children with ADHD, deciding to start medication can be challenging. One common concern is whether medications like methylphenidate (Ritalin) might affect their child’s growth and development during the crucial years of childhood and adolescence. This large-scale research study set out to address these worries by carefully examining how methylphenidate impacts physical development, particularly during puberty.

How Could ADHD Medications Affect Development?

Methylphenidate works by increasing certain brain chemicals called dopamine and norepinephrine. These same chemicals can potentially influence growth hormones and the timing of puberty. Additionally, ADHD medications often reduce appetite, which could affect growth through decreased nutrition. Understanding these mechanisms helps explain why careful research is needed to ensure these medications are safe for long-term use.

What the Research Found

The study followed three groups of children and adolescents for two years: those taking methylphenidate, those with ADHD not taking medication, and those without ADHD. The researchers carefully tracked their physical development, including height, weight, and pubertal stages (known as Tanner stages).

The key finding was reassuring: children taking methylphenidate showed normal patterns of puberty development compared to those not taking medication. While there were some small effects on growth, these were minimal and generally not concerning from a medical perspective.

The Bone Age Study

A smaller group of participants also had their “bone age” measured using X-rays of their hands and wrists. Bone age helps doctors predict adult height and assess whether a child’s physical maturation is on track. This portion of the study found that while there was a slight acceleration in bone maturation after two years of treatment, the predicted adult heights remained stable, suggesting no significant long-term impact on growth.

What This Means for You

If your child is taking or considering taking methylphenidate for ADHD, these findings provide reassurance about its safety regarding growth and development. However, it’s important to remember:

  • Regular check-ups with your healthcare provider are still important
  • Height and weight should be monitored periodically
  • Any concerns about growth or development should be discussed with your doctor
  • Individual responses to medication can vary, so personalized monitoring is key

Conclusions

  • The long-term use of methylphenidate appears safe regarding pubertal development and growth
  • While minor effects on growth may occur, these are generally not clinically significant
  • Regular monitoring by healthcare providers remains important for children taking ADHD medications
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