Authors: Pei-Yin Pan; Ulf Jonsson; Sabriye Selin Şahpazoğlu Çakmak; Alexander Häge; Sarah Hohmann; Hjalmar Nobel Norrman; Jan K. Buitelaar; Tobias Banaschewski; Samuele Cortese; David Coghill; Sven Bölte · Research

How Common Are Headaches in Children with ADHD and Are They a Side Effect of ADHD Medications?

Children with ADHD are twice as likely to experience headaches, which can also be a side effect of some ADHD medications.

Source: Pan, P. Y., Jonsson, U., Şahpazoğlu Çakmak, S. S., Häge, A., Hohmann, S., Norrman, H. N., Buitelaar, J. K., Banaschewski, T., Cortese, S., Coghill, D., & Bölte, S. (2022). Headache in ADHD as comorbidity and a side effect of medications: a systematic review and meta-analysis. Psychological Medicine, 52, 14–25. https://doi.org/10.1017/S0033291721004141

What you need to know

  • Children with ADHD are twice as likely to experience headaches compared to children without ADHD
  • About 26.6% of children with ADHD experience headaches
  • Some ADHD medications, particularly atomoxetine, guanfacine, and methylphenidate, may increase the risk of headaches as a side effect

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition that affects 5-7% of children and adolescents worldwide. Children with ADHD often struggle with inattention, hyperactivity, and impulsivity. However, many parents and healthcare providers may not be aware that headaches are also frequently experienced by children with ADHD.

This systematic review and meta-analysis examined two key questions:

  1. Are children with ADHD more likely to experience headaches compared to children without ADHD?
  2. Do common ADHD medications increase the risk of headaches as a side effect?

The researchers analyzed data from 13 epidemiological studies and 58 clinical trials to answer these questions. Let’s explore their findings and what they mean for children with ADHD and their families.

Headaches are Common in Children with ADHD

The analysis of epidemiological studies revealed that children with ADHD are about twice as likely to experience headaches compared to children without ADHD. Specifically, the odds of having headaches were 2.01 times higher in children with ADHD.

When looking at the overall prevalence, about 26.6% of children with ADHD experienced headaches. This means that roughly 1 in 4 children with ADHD may deal with headaches, which is a significant proportion.

It’s important to note that this association remained significant even when researchers accounted for factors like age, sex, and socioeconomic status. This suggests that the link between ADHD and headaches is not simply due to these other factors.

Types of Headaches in ADHD

The research also looked at specific types of headaches. Interestingly, children with ADHD seemed to have an increased risk of migraines, but not tension-type headaches. Migraines are typically more severe and can be accompanied by symptoms like nausea, sensitivity to light and sound, and visual disturbances.

However, it’s worth noting that headache types in children can be challenging to classify. Headache patterns often change over time, and different types of headaches may exist on a continuum rather than as distinct categories.

ADHD Medications and Headaches

The second part of the study examined whether common ADHD medications increase the risk of headaches as a side effect. The researchers analyzed data from clinical trials of various ADHD medications. Here’s what they found:

  1. Atomoxetine: This non-stimulant medication was associated with an increased risk of headaches. The odds of experiencing headaches were 1.29 times higher in children taking atomoxetine compared to those taking a placebo.

  2. Guanfacine: Another non-stimulant medication, guanfacine was also linked to a higher risk of headaches. The odds of headaches were 1.43 times higher compared to placebo.

  3. Methylphenidate: This commonly prescribed stimulant medication was associated with an increased risk of headaches. The odds of experiencing headaches were 1.33 times higher compared to placebo.

  4. Other medications: For amphetamines, bupropion, clonidine, and modafinil, the researchers did not find statistically significant associations with headaches. However, they noted that more research is needed due to limited data for some of these medications.

It’s important to understand that while these medications were associated with an increased risk of headaches, the overall risk is still relatively low. The majority of children taking these medications do not experience headaches as a side effect.

Implications for Children with ADHD and Their Families

These findings have several important implications for children with ADHD and their families:

  1. Awareness: Parents and healthcare providers should be aware that headaches are common in children with ADHD. If a child with ADHD complains of frequent headaches, it’s important to take these complaints seriously and not dismiss them as unrelated to ADHD.

  2. Monitoring: When starting ADHD medication, particularly atomoxetine, guanfacine, or methylphenidate, it’s important to monitor for headaches as a potential side effect. However, remember that most children do not experience significant side effects.

  3. Communication: Open communication between parents, children, and healthcare providers is crucial. If a child experiences frequent or severe headaches, whether they’re taking medication or not, this should be discussed with their doctor.

  4. Individualized treatment: The choice of ADHD medication should be individualized based on each child’s specific needs and potential side effects. If headaches become a significant issue, the doctor may consider adjusting the medication or trying a different option.

  5. Holistic management: Managing ADHD involves more than just medication. Behavioral strategies, educational support, and lifestyle factors (like good sleep habits and regular exercise) are all important parts of comprehensive ADHD care. These approaches may also help in managing headaches.

Conclusions

  • Children with ADHD are about twice as likely to experience headaches compared to their peers without ADHD.
  • Some ADHD medications, particularly atomoxetine, guanfacine, and methylphenidate, may increase the risk of headaches as a side effect.
  • Awareness, monitoring, and open communication are key in managing both ADHD and potential headaches in affected children.

While these findings highlight an important association between ADHD and headaches, they also underscore the need for individualized care. Every child with ADHD is unique, and their treatment plan should be tailored to their specific needs and challenges. By being aware of the potential for headaches and working closely with healthcare providers, families can help ensure the best possible outcomes for children with ADHD.

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