Authors: Hsien-Jane Chiu; Cheuk-Kwan Sun; Yu-Shian Cheng; Ming Yu Wang; Ruu-Fen Tzang; Feng-Li Lin; Ying-Chih Cheng; Weilun Chung · Research

How Effective Are Psychostimulants for Treating ADHD in Preschool Children?

A study examines the effectiveness and safety of psychostimulant medications for treating ADHD symptoms in preschool children.

Source: Chiu, H. J., Sun, C. K., Cheng, Y. S., Wang, M. Y., Tzang, R. F., Lin, F. L., Cheng, Y. C., & Chung, W. (2023). Efficacy and tolerability of psychostimulants for symptoms of attention-deficit hyperactivity disorder in preschool children: A systematic review and meta-analysis. European Psychiatry, 66(1), e24, 1-10. https://doi.org/10.1192/j.eurpsy.2023.11

What you need to know

  • Psychostimulant medications appear to be effective in treating ADHD symptoms in preschool children, especially for hyperactivity and impulsivity.
  • The medications seem to work better for older preschool children, boys, and with longer treatment duration.
  • While generally well-tolerated, decreased appetite was a notable side effect of psychostimulant use in preschoolers.
  • More research is needed to confirm these findings due to limitations in the current evidence.

Understanding ADHD in Preschool Children

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition that affects about 5% of school-age children worldwide. However, diagnosing and treating ADHD in preschool children (under 6 years old) can be challenging.

In preschoolers, ADHD often shows up as:

  • Difficulty paying attention
  • Excessive physical activity (hyperactivity)
  • Acting without thinking (impulsivity)
  • Disruptive behaviors like tantrums or aggression
  • Struggles with parent-child relationships

While behavioral therapies are often recommended as the first treatment for preschoolers with ADHD, sometimes medications called psychostimulants are considered. This study aimed to examine how well these medications work for treating ADHD symptoms in young children and whether they’re safe to use.

What the Research Found

The researchers combined data from nine previous studies involving 544 preschool children with ADHD symptoms. Here’s what they discovered:

Effectiveness of Psychostimulants

  1. Overall symptoms: Psychostimulants were found to be moderately effective in reducing overall ADHD symptoms, based on reports from both parents and teachers.

  2. Hyperactivity and impulsivity: The medications seemed to work particularly well for these symptoms, especially when observed by teachers.

  3. Inattention: While there was some improvement in attention problems, the effect was smaller compared to hyperactivity/impulsivity.

  4. Objective measures: Only two studies used standardized tests to measure attention. These showed some improvement in attention, but the results weren’t statistically significant.

Factors Affecting Treatment Success

The study found that psychostimulants tended to work better:

  • In older preschool children
  • For boys compared to girls
  • With longer treatment duration

Safety and Side Effects

Generally, psychostimulants were well-tolerated by preschool children. The main side effect observed was decreased appetite, which was significantly more common in children taking psychostimulants compared to those taking a placebo.

Other potential side effects like irritability, sleep problems, crying, and anxiety were slightly more common with psychostimulants, but the difference wasn’t statistically significant.

Importantly, the study didn’t find significant effects on heart rate or blood pressure, which have been concerns with psychostimulant use in older children and adults.

Understanding the Limitations

While these findings are promising, it’s important to understand some limitations of the research:

  1. Small sample size: With only 544 children across nine studies, more research is needed to confirm these results.

  2. Short-term focus: Most studies only looked at treatment effects over a few weeks. We don’t know as much about long-term effects.

  3. Potential bias: Some studies excluded children who hadn’t responded well to psychostimulants in the past, which could overestimate the medications’ effectiveness.

  4. Varied measurements: Different studies used different ways to measure ADHD symptoms, making it harder to compare results.

  5. Limited geographic scope: All studies were conducted in North America, so the results might not apply to children in other parts of the world.

What This Means for Families

If you’re a parent of a preschool child with ADHD symptoms, this research suggests that psychostimulant medications might be helpful, especially for managing hyperactivity and impulsivity. However, it’s crucial to remember that every child is different, and what works for one may not work for another.

The decision to use medication should always be made in consultation with a healthcare provider who knows your child’s specific situation. They can help weigh the potential benefits against the risks and discuss other treatment options, like behavioral therapy.

Remember that ADHD treatment often involves a combination of approaches, and medication is just one potential tool. Early intervention is important, as untreated ADHD in preschoolers can lead to difficulties with school readiness and increase the risk of other mental health issues later in life.

Conclusions

  • Psychostimulant medications show promise in treating ADHD symptoms in preschool children, particularly hyperactivity and impulsivity.
  • These medications appear to be generally safe for preschoolers, with decreased appetite being the main side effect to watch for.
  • More research is needed to confirm these findings and to understand the long-term effects of psychostimulant use in very young children.

While this study provides valuable insights, it’s important to approach ADHD treatment as a collaborative process involving parents, healthcare providers, and often educators. The goal is to find the best approach to help each child thrive, which may or may not include medication.

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