Authors: Rami Darwich; Mahyar Etminan; Bonnie He; Brennan Eadie · Research

Can ADHD Medications Increase Your Risk of Developing Glaucoma?

New research reveals important links between common ADHD medications and increased risk of different types of glaucoma

Source: Darwich, R., Etminan, M., He, B., & Eadie, B. (2024). Medications for Attention Deficit Hyperactivity Disorder Associated with Increased Risk of Developing Glaucoma. Eye. https://doi.org/10.1038/s41433-024-03100-6

What you need to know

  • ADHD medications can increase the risk of developing certain types of glaucoma
  • Different ADHD medications affect glaucoma risk in different ways
  • Regular eye pressure checks are important for people taking ADHD medications

The Growing Use of ADHD Medications

Attention deficit hyperactivity disorder (ADHD) affects millions of people worldwide. The condition is typically treated with medications that help improve focus and reduce impulsivity. These medications fall into two main categories: stimulants (like amphetamines and methylphenidate) and non-stimulants (like atomoxetine). While these medications effectively manage ADHD symptoms, researchers have been investigating their potential side effects, particularly on eye health.

Understanding Glaucoma Types

Before diving into the research findings, it’s helpful to understand the two main types of glaucoma discussed in the study:

Open-angle glaucoma (OAG) is the most common form, developing slowly as pressure builds up in the eye due to poor drainage. Think of it like a slow-clogging sink drain.

Angle-closure glaucoma (ACG) is less common but more serious, occurring when the iris blocks fluid drainage suddenly - similar to placing a stopper directly over the drain. This can cause rapid pressure buildup and requires immediate medical attention.

The Research Findings

In this large study of over 240,000 people taking ADHD medications, researchers discovered some important patterns:

Amphetamines and atomoxetine users had about twice the risk of developing angle-closure glaucoma compared to non-users. However, these medications didn’t significantly increase the risk of open-angle glaucoma.

Methylphenidate users showed a different pattern - they had a higher risk of developing open-angle glaucoma but not angle-closure glaucoma.

Why Different Medications Have Different Effects

The researchers believe these varying effects might be related to how long each medication stays active in the body. Medications that last longer in the system (like amphetamines and atomoxetine) may keep pupils dilated for extended periods, potentially increasing angle-closure glaucoma risk. This effect might be particularly important at night when pupils naturally dilate.

The relationship between methylphenidate and open-angle glaucoma might involve different mechanisms, such as how the medication affects certain chemicals in the body that influence eye pressure.

What This Means for You

If you take ADHD medication, don’t panic - but do be proactive about your eye health:

  1. Schedule regular eye exams, including pressure checks
  2. Be aware of glaucoma symptoms (like eye pain, blurred vision, or seeing halos around lights)
  3. Tell your eye doctor about all medications you’re taking
  4. Seek immediate medical attention if you experience sudden eye pain or vision changes
  5. Discuss any concerns about medication effects with your prescribing doctor

For parents of children on ADHD medications, ensure regular eye check-ups are part of their healthcare routine.

Conclusions

  • Different ADHD medications carry different risks for specific types of glaucoma
  • Regular eye exams are essential for anyone taking ADHD medications
  • The benefits of ADHD medication often outweigh the risks, but monitoring is important
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