Authors: F. Oliva; C. Mangiapane; G. Nibbio; P. Berchialla; N. Colombi; F.D. Vigna-Taglianti · Research
How Common Is Cocaine Use Among Adults with ADHD?
A meta-analysis examining rates of cocaine use and cocaine use disorder in adults diagnosed with ADHD
Source: Oliva, F., Mangiapane, C., Nibbio, G., Berchialla, P., Colombi, N., & Vigna-Taglianti, F. D. (2020). Prevalence of cocaine use and cocaine use disorder among adult patients with attention-deficit/hyperactivity disorder: A systematic review and meta-analysis. Journal of Psychiatric Research, 135, 60-71. https://doi.org/10.1016/j.jpsychires.2020.11.021
What you need to know
- About 26% of adults with ADHD have used cocaine at some point in their lives
- Around 10% of adults with ADHD develop a cocaine use disorder
- Adults with ADHD should be screened for cocaine use and referred for treatment if needed
The ADHD-Cocaine Connection
Living with ADHD as an adult comes with unique challenges. The persistent patterns of inattention, hyperactivity, and impulsivity that characterize ADHD can make it difficult to maintain focus at work, manage relationships, and regulate emotions. For some adults with ADHD, these struggles may lead them to seek relief through substance use, including cocaine.
Why Study This Link?
There are several important reasons why researchers wanted to better understand the relationship between ADHD and cocaine use:
Cocaine and common ADHD medications like methylphenidate affect similar pathways in the brain, specifically those involving dopamine - a neurotransmitter involved in attention, motivation, and reward.
Adults with ADHD often show higher levels of impulsivity and risk-taking behavior, which may increase their likelihood of experimenting with substances.
Many adults with ADHD have co-occurring mental health conditions that can increase vulnerability to substance use.
What the Research Found
After analyzing data from multiple studies involving over 3,000 adults with ADHD, researchers found that:
- Approximately one in four (26%) adults with ADHD had used cocaine at some point
- About one in ten (10%) developed a cocaine use disorder
- These rates are significantly higher than those found in the general population
- The risk appears higher for younger adults and those receiving treatment in clinical settings
Understanding the Brain Chemistry
The study’s findings make sense when we consider the neurobiology involved. Adults with ADHD typically have differences in their brain’s dopamine system, including:
- Higher density of dopamine transporters, which remove dopamine too quickly from neural synapses
- Reduced dopamine activity in brain regions controlling attention and reward
- Altered function in brain circuits regulating impulse control
Both cocaine and ADHD medications work by affecting dopamine levels in the brain. This may help explain why some people with untreated ADHD might turn to cocaine as a form of self-medication.
What This Means for You
If you or a loved one has ADHD, these findings highlight the importance of:
- Being aware of the increased risk for substance use
- Having open conversations with healthcare providers about substance use
- Getting proper treatment for ADHD symptoms
- Seeking help promptly if substance use becomes a concern
- Understanding that substance use may be an attempt to self-medicate untreated ADHD symptoms
Conclusions
- Adult ADHD significantly increases the risk of cocaine use and development of cocaine use disorder
- The shared effects of cocaine and ADHD medications on brain dopamine systems may help explain this connection
- Early screening and appropriate treatment of both ADHD and substance use issues is crucial